Marcelo Alves da Silva Mori

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Institute of Biology  – University of Campinas

Laboratory of Biology of Aging

The main purpose of our lab is to identify and characterize molecular mechanisms involved in the aging process and in response to dietary interventions. We pay particular interest to understand how metabolism contributes to the genesis of age-related diseases like type 2 diabetes, cardiovascular diseases, and neurodegenerative diseases. We focus on the fat tissue – an important site of metabolic integration in multicellular organisms – and ask ourselves how this tissue responds to changes in energy balance and signals to other tissues to inform them about these changes. If not adjusted, this mechanism leads to several chronic diseases, especially in middle aged and elderly individuals. We identified that this control is at least in part exerted by changes in microRNA biogenesis in adipose tissue. When regulated, this process affects animal susceptibility to oxidative stress and influences lifespan.

TEAM

Technical staff

  • Elzira Elisabeth Saviani

Research Fellow

  • Adriana Leandra Santoro
  • Felippe Mousovich Neto
  • Henver Simionato Brunetta
  • Tereza Cristina Minto Fontes Cal

pHD

  • Carlos Alberto Vergani Junior
  • Deisi Lilian Braga Shimo
  • Diogo de Moraes
  • Gabriel Palermo Ruiz
  • Gerson Profeta de Souza
  • Guilherme Tonon da Silva
  • Letícia de Souza Figueiredo
  • Mehmet Dinçer İnan
  • Raissa Guimarães Ludwig
  • Silas Pinto da Silva
  • Thiago Leite Knittel

Scientific Initiation

  • Raul Gobato da Costa
  • Vinicius Franco de Freitas

scholarship SAE (Student Support Service)

  • Jadyson Melo Simas
  • Jéssica Rodrigues de Andrade
  • Leticia Gabriela Silva

main articles

• Rocha AL, de Lima TI, Profeta GS, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA. Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci. Adv. 2020 Dec 2;6(49):eabc6250.

• Brandão BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL, Branquinho JL, Razolli D, Pinto S, Nielsen TS, Festuccia WT, Martins AS, Guerra BA, Knittel TL, Søgaard D, Larsen S, Helge JW, Brandauer J, Velloso LA, Emanuelli B, Kornfeld JW, Kahn CR, Vienberg SG, Zierath JR, Treebak JT, Mori MA. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23932-23941.

• Guerra BA, Brandão BB, Pinto SS, Salgueiro WG, De-Souza EA, Reis FCG, Batista TM, Cavalcante-Silva V, D’Almeida V, Castilho BA, Carneiro EM, Antebi A, Festuccia WT, Mori MA*. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. Mol Metab. 2019 Nov; 27: 124-135.

• Mori MA, Ludwig RG, Garcia-Martin R, Brandão BB, Kahn CR. Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease. Cell Metab. 2019 Aug 14. pii: S1550-4131(19)30384-5.

• De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Pinca, AP, Antebi A, Pasquinelli A, Massirer KB, Mori MA. RNA Interference May Result in Unexpected Phenotypes in Caenorhabditis elegans. Nucleic Acid Research. 2019 Mar 6. pii: gkz154.

• Pinto S, Sato VN, De-Souza EA, Ferraz RC, Camara H, Pinca APF, Mazzotti DR, Lovci MT, Tonon G, Lopes-Ramos CM, Parmigiani RB, Wurtele M, Massirer KB, Mori MA. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox Biol. 2018: 18:84-92.

• Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakagushi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK Gorder P, Kahn CR. Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues. Nature. 2017;542(7642):450-455.

• Ferraz RC, Camara H, de Souza EA, Pinto S, Pinca AP, Sato VN, Silva RC, Castilho BA, Mori MA. IMPACT is a Constitutive Inhibitor of GCN2 that Limits Lifespan in C. elegans. BMC Biology. 2016 Oct 7;14(1):87.

• Reis FC, Branquinho JL, Brandão BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA. Fat-specific Dicer Deficiency Accelerates Aging and Mitigates Several Effects of Dietary Restriction in Mice. Aging-US. 2016; 8(5): Online.

• Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 5;16(3):336-47. Citações em MyCitations: 233