Antônio C. Boschero

Institute of Biology  – University of Campinas

Laboratório do Pâncreas Endócrino e Metabolismo

Currently, we investigate the mechanisms involved with loss of function and death of pancreatic beta cells in response to different stress conditions. We do our studies in cell lines and animal models in different periods of life (fetal, neonatal and pregnancy). More specifically, we study the following topics related to beta cells: signaling pathways involved in control of function and cell mass; endoplasmic reticulum stress; inflammatory pathways; oxidative stress; possible beneficial effects of treatments with hormones and peptides.

TEAM

TECHNICAL STAFF

• Emerielle Cristine Vanzela

RESEARCH FELLOW

• Sandra Mara Ferreira
• José Maria Costa Júnior

PHD

• Cristiane dos Santos
• Gabriela Alves Bronczek
• Carine Marmentini

main discoveries

• The elucidation of the mechanisms by which glucose stimulates insulin secretion [Link to paper]
• Prolactin’s functions in maturating the secretory response of insulin-producing cells [Link to paper]
• Role of muscarinic receptors in the insulin secretion process [Link to paper]

main articles

01. Hyperinsulinemia is associated with increasing insulin secretion but not with decreasing insulin clearance in an age-related metabolic dysfunction mice model. Kurauti MA,  Ferreira SM, Soares GM, Vettorazzi  JF, Carneiro EM, Boschero AC,  Costa-Júnior JM. J Cell Physiol. 2018 Oct 28. doi: 10.1002/jcp.27667.

02. Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis. Borck PC, Batista TM, Vettorazzi JF, Soares GM, Lubaczeuski C, Guan D, Boschero AC, Vieira E, Lazar MA, Carneiro EM. Metabolism. 2018 Aug; 85:250-258. doi: 10.1016/j.metabol.2018.05.002.

03. Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition. Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F. J Mol Endocrinol. 2018 Jul;61(1):25-36. doi: 10.1530/JME-16-0257.

04. Protein malnutrition potentiates the amplifying path way of insulin secretion in adult obese mice. Leite NC, de Paula F, Borck PC, Vettorazzi JF, Branco RC, Lubaczeuski C, Boschero AC, Zoppi CC, Carneiro EM. Sci Rep.2016 Sep 16;6:33464. doi: 10.1038/srep33464.

05. Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme. Protzek AO, Rezende LF, Costa-Júnior JM, Ferreira SM, Cappelli AP, de   Paula FM, de Souza JC, Kurauti MA, Carneiro EM, Rafacho A, Boschero AC. J Steroid Biochem Mol Biol.2016 Jan;155(Pt A):1-8. doi: 10.1016/j.jsbmb.2015.09.020.

06. Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice. Kurauti MA, Freitas-Dias R, Ferreira SM, Vettorazzi JF, Nardelli TR, Araujo HN, Santos GJ, Carneiro EM, Boschero AC, Rezende LF, Costa-Júnior JM. PLoS One.2016 Jul 28;11(7):e0160239. doi: 10.1371/journal.pone.0160239.

07. Acute exercise restores insulin clearance in diet-induced obese mice. Kurauti MA, Costa-Júnior JM, Ferreira SM, Dos Santos GJ, Protzek AO, Nardelli TR, de Rezende LF, Boschero AC. J Endocrinol.2016 Jun;229(3):221-32. doi: 10.1530/JOE-15-0483.

08. Endurance training inhibits insulin clearance and IDE expression in Swiss mice. Costa-Júnior JM, Ferreira SM, Protzek AO, Santos GJ, Cappelli AP, Silveira LR, Zoppi C, de Oliveira CA, Boschero AC, Carneiro EM, Rezende LF. J Endocrinol.2016 Jun;229(3):221-32. doi: 10.1530/JOE-15-0483.

09. Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. Souza JC, Vanzela EC, Ribeiro RA, Rezende LF, de Oliveira CA, Carneiro  EM, Oliveira HC, Boschero AC. Biochim Biophys Acta.2013 Apr;1831(4):769-75. doi: 10.1016/j.bbalip.2012.12.013.

10. Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling. Paula FM, Leite NC, Vanzela EC, Kurauti MA, Freitas-Dias R, Carneiro EM, Boschero AC, Zoppi CC. FASEB J.2015 May;29(5):1805-16. doi: 10.1096/fj.14-264820