Letícia Martins Ignácio de Souza Zimmermann

Faculty of Applied Sciences – State University of Campinas  

Laboratory of Metabolic Disorders  

Metabolic programming of fetal and neonatal outcomes: the role of maternal and feto-placental interface. The role of nutritional, metabolic and dietetic status in maternal adaptations and in developmental origins of diseases, especially obesity and comorbidities.

TEAM

PHD

• Ana Paula Varela Sanches
• Josilene Lopes de Oliveira
• Maíra Schuchter Ferreira

Master

• Bruna de Souza Lima

Scientific Initiation

• Julia Silva Salomão

MAIN DISCOVERIES

Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice and maternal resistance to diet-induced obesity partially protects offspring from early metabolic disturbances (Sanches et al, 2021; Simino et al, 2021).

MAIN ARTICLES

1) Sanches APV, de Oliveira JL, Ferreira MS, Lima BS, Miyamoto JÉ, Simino LAP, Torsoni MA, Torsoni AS, Milanski M, Ignácio-Souza LM. Obesity phenotype induced by high-fat diet leads to maternal-fetal constraint, placental inefficiency, and fetal growth restriction in mice. J Nutr Biochem. 2022 Mar 3:108977

2) Simino, Laís Angélica De Paula; Panzarin, Carolina ; Torsoni, Marcio Alberto; Ignácio-Souza, Letícia Martins ; Milanski, Marciane ; Torsoni, Adriana Souza. Maternal resistance to diet-induced obesity partially protects newborn and post-weaning male mice offspring from metabolic disturbances. Journal of Developmental Origins of Health and Disease, v. 1, p. 1-11, 2021.

3) Simino LAP, Panzarin C, Fontana MF, de Fante T, Geraldo MV, Ignácio-Souza LM, Milanski M, Torsoni MA, Ross MG, Desai M, Torsoni AS. MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies. Sci Rep. 2021 Apr 26;11(1):8980.

4) Ignácio-Souza LM, Reis SR, Arantes VC, Botosso BL, Veloso RV, Ferreira F, Boschero AC, Carneiro EM, Reis MA, Latorraca MQ. Protein restriction in early life is associated with changes in insulin sensitivity and pancreatic β-cell function during pregnancy. Br J Nutr. 2013 Jan 28;109(2):236-47

5) Ignacio-Souza LM, Bombassaro B, Pascoal LB, Portovedo MA, Razolli DS, Coope A, Victorio SC, de Moura RF, Nascimento LF, Arruda AP, Anhe GF, Milanski M, Velloso LA. Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology. 2014 Aug;155(8):2831-44.