Raquel Franco Leal

School of Medical Sciences – University of Campinas IBD Research Laboratory

TEAM

RESEARCH FELLOW

• Lívia Aparecida D’Avila Bitencourt Pascoal Biazzo
• Pedro Henrique Leite Bonfitto
• Beatriz Alves Guerra

PHD

• Bruno Lima Rodrigues
• Luis Eduardo Miani Gomes
• Karine Mariane Steigleder
• Livia Moreira Genaro
• Márcia Carolina Mazzaro
• Fábio Mendonça Chaim
• Marina Moreira de Castro (co-orientadora)

MASTER

• Juliana Delgado
• Natalia Souza Nunes Siqueira
• Julian Furtado Silva
• Hugo Dugolin Ceccato

SCIENTIFIC INITIATION

• Ana Paula Franceschini
• Bruna Biazon Palma
• Renato Lazarin Ricci
• Tiago Andrade Damazio
• Dante Orsetti Silva Araújo
• Filipe Botto Crispim Silva
• Gabriel Roza Silveira Batista
• Adherbal Victor Rodrigues Teixeira
• Maria Luiza Almeida

MAIN ARTICLES

1. Pascoal LB, Rodrigues PB, Genaro LM, Gomes ABDSP, Toledo-Teixeira DA, Parise PL, Bispo-Dos-Santos K, Simeoni CL, Guimarães PV, Buscaratti LI, Elston JGA, Marques-Souza H, Martins-de-Souza D, Ayrizono MLS, Velloso LA, Proenca-Modena JL, Moraes-Vieira PMM, Mori MAS, Farias AS, Vinolo MAR, Leal RF. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. Gut Microbes. 2021;13(1):1-9.
2. da Silva FAR, Pascoal LB, Dotti I, Setsuko Ayrizono ML, Aguilar D, Rodrigues BL, Arroyes M, Ferrer-Picon E, Milanski M, Velloso LA, Fagundes JJ, Salas A, Leal RF. Whole transcriptional analysis identifies markers of B, T and plasma cell signaling pathways in the mesenteric adipose tissue associated with Crohn’s disease. J Transl Med. 2020 Jan 30;18(1):44. doi: 10.1186/s12967-020-02220-3.
3. Coope A, Pascoal LB, Botezelli JD, da Silva FAR, Ayrizono MLS, Rodrigues BL, Milanski M, Carvalho RB, Fagundes JJ, Velloso LA, Leal RF. ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients. PLoS One. 2019;26;14(9):e0223105.
4. de Castro MM, Corona LP, Pascoal LB, Rodrigues BL, de Lourdes Setsuko Ayrizono M, Rodrigues Coy CS, Leal RF, Milanski M. Impaired nutritional status in outpatients in remission or with active Crohn’s disease – classified by objective endoscopic and imaging assessments. Clin Nutr ESPEN. 2019; 33:60-65.
5. Gomes LEM, da Silva FAR, Pascoal LB, Ricci RL, Nogueira G, Camargo MG, Lourdes Setsuko Ayrizono M, Fagundes JJ, Leal RF. Serum Levels of Infliximab and Anti-Infliximab Antibodies in Brazilian Patients with Crohn’s Disease. Clinics, 2019;8:74:e824.
6. Gomes LEM, da Silva FAR, Pascoal LB, Ricci RL, Nogueira G, Camargo MG, de Lourdes Setsuko Ayrizono M, Fagundes JJ, Leal RF. Authors’ Reply – Comments: Serum levels of infliximab in Brazilian patients with Crohn’s disease: what are the reasons for differences from previous studies? Clinics. 2019; 26;74:e1517.
7. Paiva NM, Pascoal LB, Negreiros LMV, Portovedo M, Coope A, Ayrizono MLS, Coy CSR, Milanski M, Leal RF. Ileal pouch of ulcerative colitis and familial adenomatous polyposis patients exhibit modulation of autophagy markers. Sci Rep (Nature), 2018; 8;8(1):2619.
8. Coope A, Pascoal LB, da Silva FAR, Botezelli JD, Ayrizono MLS, Milanski M, Camargo MG, Planell N, Portovedo M, Dias CB, Fagundes JJ, Leal RF. Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients. Int J Inflam 2017; 2017:7646859.
9. Planell N, Masamunt MC, Leal RF, Rodríguez L, Esteller M, Lozano JJ, Ramírez A, Ayrizono MLS, Coy CSR, Alfaro I, Ordás I, Visvanathan S, Ricart E, Guardiola J, Panés J, Salas A. Usefulness of Transcriptional Blood Biomarkers as a Non-invasive Surrogate Marker of Mucosal Healing and Endoscopic Response in Ulcerative Colitis. J Crohns Colitis 2017 27;11(11):1335-1346.
10. Dotti, I; Mora-Buch, R; Ferrer-Picón, E; Planell, N; Jung, P; Masamunt, MC; Leal, RF; Martín de Carpi, J; Llach, J; Ordás, I; Batlle, E; Panés, J; Salas, A. Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis. Gut 2017; 66(12):2069-2079.
11. Ward, MA; Pierre, JF; Leal, RF; Huang, Y; Shogan, BD; Dalal, SR; Weber, CR; Leone, VA; Musch, MW; An, GC; Rao, MC; Rubin, DT; Raffals, LE; Antonopoulos, DA; Sogin, ML; Hyman, NH; Alverdy, JC; Chang, EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol 2016;310(11):G973-88.
12. Silva FAR, Rodrigues BL, Ayrizono MLS, Leal RF. The immunological basis of inflammatory bowel disease. Gastroenterol Res Pract 2016; 2016:2097274.
13. Leal, RF; Planell, N; Kajekar, R; Lozano, JJ; Ordás, I; Dotti, I; Esteller, M; Masamunt, MC; Parmar, H; Ricart, E; Panés, J; Salas A. Identification of inflammatory mediators in Crohn’s disease patients unresponsive to anti-TNF-α therapy. Gut 2015; 64:233-42.
14. Portovedo M, Ignacio-Souza LM, Bombassaro B, Coope A, Reginato A, Razolli DS, Torsoni MA, Torsoni AS, Leal RF, Velloso LA, Milanski M. Saturated fatty acids modulate autophagy’s proteins in the hypothalamus. PLoS One 2015; 18;10(3):e0119850.
15. Dias CB, Milanski M, Portovedo M, Horita V, Ayrizono Mde L, Planell N, Coy CS, Velloso LA, Meirelles LR, Leal RF. Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn’s disease patients. PLoS One 2014;9(6):e98547.
16. Leal RF, Milanski M, Ayrizono Mde L, Coope A, Rodrigues VS, Portovedo M, Oliveira LM, Fagundes JJ, Coy CS, Velloso LA. Toll-like receptor 4, F4/80 and pro-inflammatory cytokines in intestinal and mesenteric fat tissue of Crohn’s disease. Int J Clin Exp Med. 2013;6(2):98-104.
17. Rodrigues VS, Milanski M, Fagundes JJ, Torsoni AS, Ayrizono ML, Nunez CE, Dias CB, Meirelles LR, Dalal S, Coy CS, Velloso LA, Leal RF. Serum levels and mesenteric fat tissue expression of adiponectin and leptin in patients with Crohn’s disease. Clin Exp Immunol. 2012;170(3):358-64.
18. Leal RF, Coy CS, Velloso LA, Dalal S, Portovedo M, Rodrigues VS, Coope A, Ayrizono ML, Fagundes JJ, Milanski M. Autophagy is decreased in mesenteric fat tissue but not in intestinal mucosae of patients with Crohn’s disease. Cell Tissue Res. 2012;350(3):549-52.
19. Paiva NM, Ayrizono ML, Milanski M, Coope A, Oliveira LM, Fagundes JJ, Velloso LA, Coy CS, Leal RF. Differential expression of TLR2, TLR4 and JNK in mucosa of ileal pouches for ulcerative colitis. Is there a role for bacterial antigen pathway in asymptomatic patients? Int J Clin Exp Med. 2011;4(3):179-86.
20. Leal RF, Ayrizono ML, Milanski M, Coope A, Fagundes JJ, Velloso LA, Coy CS. Activation of signal transducer and activator of transcription-1 (STAT-1) and differential expression of interferon-gamma and anti-inflammatory proteins in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. Clin Exp Immunol. 2010;160(3):380-5.
21. Leal RF, Coy CS, Ayrizono ML, Fagundes JJ, Milanski M, Saad MJ, Velloso LA, Góes JR. Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. Tech Coloproctol 2008;12(1):33-8.