Roberto Schreiber

School of Medical Sciences – University of Campinas

Laboratory of Cardiovascular Biology

The Laboratory of Cardiovascular Biology at FCM-UNICAMP has as main objective to investigate the genetic and epigenetic factors of cardiovascular alterations, as well as cardiac remodeling in hypertensive patients and in people with spinal cord injury. To this end, we use several molecular biology tools.

TEAM

PHD

• Elisangela Cristina Lopes Dias

MASTER

• Larissa C.M. Bueno
• Eduarda Olivia Zechetti Minin

MAIN DISCOVERIES

• Several miRNAs are associated with accelerated atherosclerosis in patients with chronic spinal cord injury and adapted sports activity seems to interfere with the serum expression of these miRNAs;
• There are large differences in the clinical and genotypic determinants of cardiac remodeling between men and women with systemic arterial hypertension;
• Genetic variants of NADPH oxidase and toll-like receptors are associated with cardiac remodeling in hypertensive patients;
• Hypertensive patients with carotid plaques have increased expression of miR-145-5p and miR-let7c, suggesting a potential role for these miRNAs as a biomarker for subclinical atherosclerosis in hypertensive individuals.

MAIN ARTICLES

1- Association of Circulating miR-145-5p and miR-let7c and Atherosclerotic Plaques in Hypertensive Patients. Minin EOZ, Paim LR, Lopes ECP, Bueno LCM, Carvalho-Romano LFRS, Marques ER, Vegian CFL, Pio-Magalhães JA, Coelho-Filho OR, Sposito AC, Matos-Souza JR, Nadruz W, Schreiber R. Biomolecules. 2021 Dec 7;11(12):1840. doi: 10.3390/biom11121840.

2- Association of carotid wall layers with atherosclerotic plaques and cardiac hypertrophy in hypertensive subjects. Carvalho-Romano LFRS, Bonafé RP, Paim LR, Marques ER, Vegian CFL, Pio-Magalhães JA, Mello DSS, de Rossi G, Coelho-Filho OR, Schreiber R, Sposito AC, Matos-Souza JR, Nadruz W Jr. J Hum Hypertens. 2021 Jun 15. doi: 10.1038/s41371-021-00565-w.

3- Association of left ventricular strain and E/e’ ratio with carotid wall layers. Carvalho-Romano LFRS, Bonafé RP, Paim LR, Marques ER, Vegian CFL, Pio-Magalhães JA, Mello DSS, Schreiber R, Sposito AC, Matos-Souza JR, Nadruz W Jr. Atherosclerosis. 2020 Oct;310:109-110. doi: 10.1016/j.atherosclerosis.2020.08.008. Epub 2020 Aug 25.

4- Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury. Lopes ECP, Paim LR, Matos-Souza JR, Calegari DR, Gorla JI, Cliquet A Jr, Lima CSP, McDonald JF, Nadruz W Jr, Schreiber R. Biosci Rep. 2019 Sep 20;39(9):BSR20190989. doi: 10.1042/BSR20190989. Print 2019 Sep 30.

5- Circulating microRNAs, Vascular Risk, and Physical Activity in Spinal Cord-Injured Subjects. Paim LR, Schreiber R, de Rossi G, Matos-Souza JR, Costa E Silva AA, Calegari DR, Cheng S, Marques FZ, Sposito AC, Gorla JI, Cliquet A Jr, Nadruz W Jr. J Neurotrauma. 2019 Mar 19;36(6):845-852. doi: 10.1089/neu.2018.5880. Epub 2018 Sep 27.

6- Reduced Sympathetic Stimulus and Angiotensin 1-7 Are Related to Diastolic Dysfunction in Spinal Cord-Injured Subjects. Schreiber R, Paim LR, de Rossi G, Matos-Souza JR, Costa E Silva AA, Nogueira CD, Azevedo ER, Alonso KC, Palomino Z, Sposito AC, Casarini DE, Gorla JI, Cliquet A Jr, Nadruz W Jr. J Neurotrauma. 2017 Aug 1;34(15):2323-2328. doi: 10.1089/neu.2016.4902. Epub 2017 Jun 14.

7- Evidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cells. Schreiber R, Mezencev R, Matyunina LV, McDonald JF. Cancer Gene Ther. 2016 Aug;23(8):241-5. doi: 10.1038/cgt.2016.23. Epub 2016 May 27.

8- Gender influences the relationship between lung function and cardiac remodeling in hypertensive subjects. Mendes PR, Kiyota TA, Cipolli JA, Schreiber R, Paim LR, Bellinazzi VR, Matos-Souza JR, Sposito AC, Nadruz W Jr. Hypertens Res. 2015 Apr;38(4):264-8. doi: 10.1038/hr.2014.168. Epub 2014 Nov 27.

9- Influence of the C242T polymorphism of the p22-phox gene (CYBA) on the interaction between urinary sodium excretion and blood pressure in an urban Brazilian population. Schreiber R, Bellinazzi VR, Sposito AC, Mill JG, Krieger JE, Pereira AC, Nadruz W Jr. PLoS One. 2013 Dec 5;8(12):e81054. doi: 10.1371/journal.pone.0081054. eCollection 2013.

10- Effect of genetic polymorphisms of vascular endothelial growth factor on left ventricular hypertrophy in patients with systemic hypertension. Lacchini R, Luizon MR, Gasparini S, Ferreira-Sae MC, Schreiber R, Nadruz W Jr, Tanus-Santos JE. Am J Cardiol. 2014 Feb 1;113(3):491-6. doi: 10.1016/j.amjcard.2013.10.034.