Andrei Carvalho Sposito

School of Medical Sciences – University of Campinas

Atherosclerosis and Vascular Biology Laboratory (Atherolab)

Aterolab was created with the purpose of continuing the line of investigation I have been focusing on for the last 20 years. The legacy of this preceding period are two prospective cohorts with very elderly patients or with myocardial infarction. From these cohorts, we have the serum library that we used to identify biomarkers of cardiovascular risk. After its creation, new studies were incorporated aimed at studying the relationship between insulin sensitivity, sleep apnea and endothelial function. The main focus of AteroLab is the identification by in vivo, ex vivo and in vitro tests of modulators of endothelial function in individuals with overt or silent atherosclerotic disease.

TEAM

TECHNICAL STAFF

• Camila Cristina Moreira Gossi

RESEARCH FELLOW

• Alejandro Rossel
• Helison Rafael do Carmo
• Ticiane Gonçalez Bovi

PHD

• Ana Claudia Cavalcante Nogueira
• Ikaro S. S. Breder
• Isabella Bonilha de Oliveira
• Joaquim de Paula Barreto Fonseca Antunes de Oliveira
• Sheila Tatsumi Kimura Medorima
• Silvio Gioppato
• Vaneza Lira Waldow Wolf

MASTER

• Nestor Sales Martins
• Pamela Cavalcante
• Vicente Hidalgo Rodrigues Fernandes

MAIN ARTICLES

1. Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. Author(s): Codo AC, et al. Source: Cell Metab. 2020 Sep 1;32(3):437-446.

2. Evolution and epidemic spread of SARS-CoV-2 in Brazil Author(s): Candido DS et al. Source: Science. 2020;369(6508):1255-1260

3. Role of LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1) as a Cardiovascular Risk Predictor: Mechanistic Insight and Potential Clinical Use. Author(s): Barreto J et al. Source: Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):153-166

4. Machine Learning Improves the Identification of Individuals With Higher Morbidity and Avoidable Health Costs After Acute Coronary Syndromes. Author(s): Carvalho LSF; et al. Source: Value Health. 2020 Dec;23(12):1570-1579.

5. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors and Incident Type 2 Diabetes: A Systematic Review and Meta-analysis With Over 96,000 Patient-Years Author(s): Carvalho, LSF et al. Source: Diabetes Care 2018; 41(2): 364-367

6. Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial. Author(s): Berwanger O et al. Source: JAMA. 2018 Apr 3;319(13):1331-1340

7. Dapagliflozin effect on endothelial dysfunction in diabetic patients with atherosclerotic disease: a randomized active-controlled trial. Author(s): Sposito, A. C. et al. Source: Cardiovasc Diabetol. 2021 Mar 26;20(1):74

8. Glucose-lowering Drugs and Hospitalization for Heart Failure: A Systematic Review and Additive-effects Network Meta-Analysis with over 500,000 Patient-Years. Author(s): Cintra, Riobaldo M. R. et al. Source: J Clin Endocrinol Metab. 2021 Jun 14:dgab428. doi: 10.1210/clinem/dgab428

9. Cardiovascular safety of naltrexone and bupropion therapy: Systematic review and meta-analyses Author(s): Sposito, A. C. et al. Source: Obes Rev. 2021 Jun;22(6):e13224

10. Increased particle size of triacylglycerol-enriched remnant lipoproteins, but not their plasma concentration or lipid content, augments risk prediction of incident type 2 diabetes. Author(s): Carvalho LSF et al. Source: Diabetologia. 2021 Feb;64(2):385-396