Ronaldo Aloise Pilli
Institute of Chemistry – University of Campinas
Laboratório de Síntese Orgânica
TEAM
TECHNICAL STAFF
- Walkyria Miyashita
RESEARCH FELLOW
- Bruno Matos Paz
- Carolyne Brustolin Braga
PHD
- Franco Della Felice
- Ian de Toledo
- Marcela Campelo Silva
- Matheus Meirelles
- Juliana Lira Reguera
- Ajmir Khan
MASTER
- Luis Henrique Defante
- Ana Leticia Pires
MAIN DISCOVERIES
- Total synthesis of pheromones (serricornin, invictolide, and sitofilure sulcatol);
- Drug synthesis (Ritalin, Prozac, etc.);
- Synthesis of macrolides (10-desoximetinolide, delactomicin, decarestrictin D, among others);
- Synthesis of alkaloids (homopumiliotoxin 223G, indollizidin 223AB, stemoamid, among others);
- Synthesis of analogues of natural products with cytotoxic activity (goniotalamin and piplartin).
MAIN ARTICLES
1. Novaes, L. F. T., Sarotti, A. M., Pilli, R. A., Total synthesis and stereochemical assignment of cryptolatifolione, RSC Advances 2015, 5, 53471-53476
2.Barcelos, R. C., Pelizzaro-Rocha, K. J., Pastre, J. C., Dias, M. P., Ferreira-Halder, C. V., Pilli, R. A., A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness, Eur. Med. Chem. 2014, 87, 745-758
3.Brito, G. A., Sarotti, A. M., Wipf, P., Pilli, R. A., Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer, Tetrahedron Lett. 2015, 56, 6664–6668.
4.Novaes, L. F. T., Sarotti, A. M., Pilli, R. A., Total Synthesis and Tentative Structural Elucidation of Cryptomoscatone E3: Interplay of Experimental and Computational Studies, J. Org. Chem. 2015, 80, 12027-12037.
5.Kido, L. A., Montico, F., Sauce, R., Macedo, A. B., Minatel, E., Vendramini-Costa, D. B., de Carvalho, J. E., Pilli, R. A., Cagnon, V. H. A., Anti-inflammatory Therapies in TRAMP mice: Delay in PCa Progression, Endocrine-related Cancer 2016, 23, 235-250.
6.Felice, F. D., Sarotti, A. M., Pilli, R. A., Catalytic Asymmetric Synthesis and Stereochemical Revision of Cryptoconcatone H, Org. Chem. 2017, 82, 9191-9197.
7.Raitz, I.,Souza Filho, R. Y., de Andrade, L. P., Correa, J. R.,. Neto, A. D., Pilli, R. A., Preferential Mitochondrial Localization of Goniothalamin Fluorescent Derivative, ACS Omega 2017, 2, 3774-3784.
8.Della Felice, F., Sarotti, A. M., Pilli, R. A., Catalytic Asymmetric Synthesis and Stereochemical Revision of (+)-Cryptoconcatone H, Org. Chem. 2017, 82, 9191-9197.
9.Brito, G. A., Della Felice, F., Luo, G., Burns, A. S., Pilli, R. A., Rychnovsky, S. Krische, M. J., Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling, Lett. 2018, 20, 4144-4147.
10.de Assis, F., Huang, X., Akiyama, M., Pilli, R. A. , Meggers, E., Visible-light Activated Catalytic Enantioselective b-Alkylation of a,b-Unsaturated 2-Acyl Imidazoles using Hantsch Esters as Radical Reservoirs, Org. Chem. 2018, 83, 10922-1093.
Instituto de Química - Sala D-353
Rua José de Castro, s/n - Cidade Universitária
Campinas - SP, 13083-970
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E-mail: [email protected]