Eduardo Rochete Ropelle

Faculdade de Ciências Aplicadas – Universidade Estadual de Campinas

Laboratório de Biologia Molecular do Exercício – LaBMEx

O laboratório investiga o efeito do exercício físico sobre a sensibilidade à insulina e sobre o metabolismo mitocondrial em modelos experimentais de obesidade e envelhecimento.

EQUIPE

Pós-Doutorado

• Carlos K. Katashima

Doutorado

• Fernanda Carneiro
• Ana Paula Morelli
• Renata Braga

Mestrado

• Matheus Biscaro Rocha

Iniciação Científica

• Scylas Andrade
• Izabela Araújo
• Daniel Dias

BOLSISTA SAE (SERVIÇO DE APOIO AO ESTUDANTE)

• Maria Laysa Capistrano Da Silva
• Victor Samuel Mendes Da Silva

INICIAÇÃO CIENTÍFICA (ENSINO MÉDIO)

• Gabriel Bombo Pierroti
• Clara Batista da Silva
• Sarah Domingues

PRINCIPAIS ARTIGOS

1 Gaspar RS, Katashima CK, Crisol BM, Carneiro FS, Sampaio I, Silveira LDR, Silva ASRD, Cintra DE, Pauli JR, Ropelle ER. Physical exercise elicits UPR^mt in the skeletal muscle: The role of c-Jun N-terminal kinase. Mol Metab. 2023.

2Katashima CK, de Oliveira Micheletti T, Braga RR, Gaspar RS, Goeminne LJE, Moura-Assis A, Crisol BM, Brícola RS, Silva VRR, de Oliveira Ramos C, da Rocha AL, Tavares MR, Simabuco FM, Matheus VA, Buscaratti L, Marques-Souza H, Pazos P, Gonzalez-Touceda D, Tovar S, Del Carmen García M, Neto JCR, Curi R, Hirabara SM, Brum PC, Prada PO, de Moura LP, Pauli JR, da Silva ASR, Cintra DE, Velloso LA, Ropelle ER. Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism. Sci Adv. 2022.

3 Muñoz VR, Gaspar RC, Severino MB, Macêdo APA, Simabuco FM, Ropelle ER, Cintra DE, da Silva ASR, Kim YB, Pauli JR. Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice. Front Immunol. 2021.

4 Ropelle ER, da Silva ASR, Cintra DE, de Moura LP, Teixeira AM, Pauli JR. Physical Exercise: A Versatile Anti-Inflammatory Tool Involved in the Control of Hypothalamic Satiety Signaling. Exerc Immunol Rev. 2021.

5 Braga RR, Crisol BM, Brícola RS, Sant’ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER. Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR^mtin the hypothalamus of mice. Sci Rep. 2021.

6 Vieira RFL, Muñoz VR, Junqueira RL, de Oliveira F, Gaspar RC, Nakandakari SCBR, Costa SO, Torsoni MA, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Zaghloul I, Mekary RA, Pauli JR. Time-restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high-fat diet. J Physiol. 2022.

7 Cordeiro AV, Peruca GF, Braga RR, Brícola RS, Lenhare L, Silva VRR, Anaruma CP, Katashima CK, Crisol BM, Barbosa LT, Simabuco FM, da Silva ASR, Cintra DE, de Moura LP, Pauli JR, Ropelle ER. High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice. Geroscience. 2021.

8 Cordeiro AV, Brícola RS, Braga RR, Lenhare L, Silva VRR, Anaruma CP, Katashima CK, Crisol BM, Simabuco FM, Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER. Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPR^mt in the Skeletal Muscle of Aged Mice. J Gerontol A Biol Sci Med Sci. 2020.

9 Nakandakari SCBR, Muñoz VR, Kuga GK, Gaspar RC, Sant’Ana MR, Pavan ICB, da Silva LGS, Morelli AP, Simabuco FM, da Silva ASR, de Moura LP, Ropelle ER, Cintra DE, Pauli JR. Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice. Brain Behav Immun. 2019.

10 Crisol BM, Veiga CB, Braga RR, Lenhare L, Baptista IL, Gaspar RC, Muñoz VR, Cordeiro AV, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER. NAD+ precursor increases aerobic performance in mice. Eur J Nutr. 2020.