Patrícia de Oliveira Prada

Instituto de Biologia – Universidade Estadual de Campinas

Departamento de Biologia Estrutural e Funcional

EQUIPE

Doutorado

• Clara Machado Campolim

Iniciação Científica

• Bianca Camilo Schimenes
• Fernanda Xavier

Principais Descobertas

Recentemente, durante meu Pós-Doc no Max Planck Institute for Metabolism Research no grupo do Prof. Jens Brüning, desenvolvi técnicas como fiber photometry, DREADD, RNAscope, trabalhei com diferentes modelos animais transgênicos cre-lox e dre-rox, para aprofundar o entendimento sobre os circuitos neuronais que regulam a ingestão alimentar e o metabolismo energético.

PRINCIPAIS ARTIGOS

1. Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation – a mini-review. Campolim CM, Schimenes BC, Veras MM, Kim YB, Prada PO. Front Immunol. 2024 Jun 12;15:1401800. doi: 10.3389/fimmu.2024.1401800. eCollection 2024. PMID: 38933275 Free PMC article. Review.

2. Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release. Zhou X, Stine C, Prada PO, Fusca D, Assoumou K, Dernic J, Bhat MA, Achanta AS, Johnson JC, Pasqualini AL, Jadhav S, Bauder CA, Steuernagel L, Ravotto L, Benke D, Weber B, Suko A, Palmiter RD, Stoeber M, Kloppenburg P, Brüning JC, Bruchas MR, Patriarchi T. Nat Commun. 2024 Jun 25;15(1):5353. doi: 10.1038/s41467-024-49712-0. PMID: 38918403 Free PMC article.

3. Multiple metabolic signals in the CeA regulate feeding: The role of AMPK. Castro G, Mendes NF, Weissmann L, Quaresma PGF, Saad MJA, Prada PO. Mol Cell Endocrinol. 2024 Aug 1;589:112232. doi: 10.1016/j.mce.2024.112232. Epub 2024 Apr 10. PMID: 38604549

4. CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion. Norberto S, Assalin HB, Guadagnini D, Tobar N, Boer PA, Kang MC, Saad MJA, Kim YB, Prada PO. Front Endocrinol (Lausanne). 2023 Aug 10;14:1172835. doi: 10.3389/fendo.2023.1172835. eCollection 2023. PMID: 37635967 Free PMC article.

5. Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4. Oliveira Ferreira CK, Campolim CM, Zordão OP, Simabuco FM, Anaruma CP, Pereira RM, Boico VF, Salvino LG, Costa MM, Ruiz NQ, de Moura LP, Saad MJA, Costa SKP, Kim YB, Prada PO. Toxicol Rep. 2023 Jun 15;11:10-22. doi: 10.1016/j.toxrep.2023.06.002. eCollection 2023 Dec. PMID: 37383489

6. Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4. Oliveira Ferreira CK, Campolim CM, Zordão OP, Simabuco FM, Anaruma CP, Pereira RM, Boico VF, Salvino LG, Costa MM, Ruiz NQ, de Moura LP, Saad MJA, Costa SKP, Kim YB, Prada PO. Toxicol Rep. 2023 Jun 15;11:10-22. doi: 10.1016/j.toxrep.2023.06.002. eCollection 2023 Dec. PMID: 37383489

7. Metformin acts in the gut and induces gut-liver crosstalk. Tobar N, Rocha GZ, Santos A, Guadagnini D, Assalin HB, Camargo JA, Gonçalves AESS, Pallis FR, Oliveira AG, Rocco SA, Neto RM, de Sousa IL, Alborghetti MR, Sforça ML, Rodrigues PB, Ludwig RG, Vanzela EC, Brunetto SQ, Boer PA, Gontijo JAR, Geloneze B, Carvalho CRO, Prada PO, Folli F, Curi R, Mori MA, Vinolo MAR, Ramos CD, Franchini KG, Tormena CF, Saad MJA. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2211933120. doi: 10.1073/pnas.2211933120. Epub 2023 Jan 19. PMID: 36656866 Free PMC article.

8. Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus. de Oliveira Micheletti T, Cassia Dos Santos A, Rocha GZ, Silva VRR, Quaresma PGF, Assalin HB, Junqueira FS, Ropelle ER, Oliveira AG, Saad MJA, Prada PO. Front Physiol. 2022 Nov 14;13:956116. doi: 10.3389/fphys.2022.956116. eCollection 2022. PMID: 36452038 Free PMC article.

9. Evidence for a neuromuscular circuit involving hypothalamic interleukin-6 in the control of skeletal muscle metabolism. Katashima CK, de Oliveira Micheletti T, Braga RR, Gaspar RS, Goeminne LJE, Moura-Assis A, Crisol BM, Brícola RS, Silva VRR, de Oliveira Ramos C, da Rocha AL, Tavares MR, Simabuco FM, Matheus VA, Buscaratti L, Marques-Souza H, Pazos P, Gonzalez-Touceda D, Tovar S, Del Carmen García M, Neto JCR, Curi R,  Hirabara SM, Brum PC, Prada PO, de Moura LP, Pauli JR, da Silva ASR, Cintra DE, Velloso LA, Ropelle ER. Sci Adv. 2022 Jul 29;8(30):eabm7355. doi: 10.1126/sciadv.abm7355. Epub 2022 Jul 29. PMID: 35905178 Free PMC article.

10. Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice. Campolim CM, Weissmann L, Ferreira CKO, Zordão OP, Dornellas APS, de Castro G, Zanotto TM, Boico VF, Quaresma PGF, Lima RPA, Donato J Jr, Veras MM, Saldiva PHN, Kim YB, Prada PO. Sci Rep. 2020 Jun 23;10(1):10160. doi: 10.1038/s41598-020-67040-3. PMID: 32576879 Free PMC article.