José A. Rocha Gontijo

Faculdade de Ciências Médicas – Universidade de Campinas

Laboratório de Metabolismo Hidrossalino e Programação Fetal

EQUIPE

Biólogos do laboratório

•  Ize Penhas de Lima

Doutorado

• Julia Sevá Gomes
• Orion Ribeiro
• Gabriela Leme Lamana
• Luara Fernades Argenton Duarte
• Augusto Henrique Custódio
• Ana Rita Sainati Ajona
• Marcelo Gustavo lopes
• Marina Silva Folguieri
• Vinícius Schiavinatto Mariano

Iniciação Científica

• Eduarda Vitta de Mello

BOLSISTA SAE (SERVIÇO DE APOIO AO ESTUDANTE)

• Laura Aguiar Leal
• Marina Cristina da Silva

PRINCIPAIS DESCOBERTAS

1. Repercussões da restrição proteica gestacional ou estresse gestacional sobre comportamento, a morfologia e funcionalidade de rins, coração e áreas do SNC em roedores jovens, adultos e senis;
2. Desenvolvimento de modelo Alzheimer símile em ratos e camundongos;
3. Repercussões da restrição proteica gestacional durante o desenvolvimento de ossos, dentes, pulmão e fígado.

PRINCIPAIS ARTIGOS 

1. Alimentação, comida, ciência e arte. SS Fabiana de Menezes Soares, José Antônio Rocha Gontijo. Revista da UFMG, Belo Horizonte, MG 28 (3), 9-13, 2023.

2. Gestational protein restriction alters early amygdala neurochemistry in male offspring. DB Torres, A Lopes, AJ Rodrigues, MG Lopes, AP Ventura-Silva, N Sousa, Gontijo JAR, Boer PA. Nutritional Neuroscience 26 (11), 1103-1119, 2023.

3. Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development. JS Gomes, LB Sene, GL Lamana, PA Boer, JAR Gontijo. Plos one 18 (5), e0266293, 2023.

4. Metformin acts in the gut and induces gut-liver crosstalk. PNAS 120 (https://doi.org/10.1073/pnas.2211933120), e2211933120, 2023.

5. Transcriptome and morphological analysis on the heart in gestational protein-restricted aging male rat offspring. MS Folguieri, ATB Franco, AS Vieira, JAR Gontijo, PA Boer. Frontiers in Cell and Developmental Biology 10, 892322, 2022.

6. Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? GB Grigoletti-Lima, MG Lopes, ATB Franco, AM Damico, PA Boer, Gontijo JAR. doi:10.3233/ADR-210297 6 (1), 17-30, 2022.

7. Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development. Vinicius S. Mariano, Patricia Aline Boer, Gontijo JAR. doi:10.3389/fphys.2021.704819 12 (Frontiers in Physiology), 1-17.

8. Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis. L de Barros Sene, GL Lamana, A Schwambach Vieira, WR Scarano, Gontijo JAR, Boer PA. Frontiers in Physiology 12, 648056, 2021.

9. Gestational and breastfeeding low-protein intake on blood pressure, kidney structure, and renal function in male rat offspring in adulthood. GL Lamana, ALL Ferrari, JAR Gontijo, PA Boer. Frontiers in Physiology 12, 510, 2021.

10. Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus. LB Sene, WR Scarano, A Zapparoli, JAR Gontijo, PA Boer. PLoS One 16 (2), e0246289, 2021.

11. Early morphological and neurochemical changes of the bed nucleus of stria terminalis (BNST) in gestational protein-restricted male offspring (in press). Torres DB, Lopes A, Rodrigues AJ, Ventura-Silva AP, Sousa N, Gontijo JAR, Boer PA. Nutritional Neuroscience; 10.1080/1028415X.2024.2320498, 2024.