Renata Frazão

Institute of Biomedical Sciences – University of São Paulo

Neuroelectrophysiology Laboratory – Departament of Anatomy

Environmental cues in association with different hormones and circadian-secreted neuropeptides are responsible for modulating the hypothalamic-pituitary-gonadal (HPG) axis, stimulating sexual maturation, and synchronizing the ovulatory cycle in adulthood. Our laboratory investigates the action of different hormones and neuropeptides on hypothalamic neuronal groups essential for the onset of puberty and the establishment of reproductive functions. Using electrophysiological, neuroanatomical, behavioral, and pharmacogenetic approaches, our goal is to contribute to the understanding of how different pieces of information are integrated to modulate the central components of the HPG axis, and therefore the reproduction.

TEAM

PHD

• Guilherme Alves
• Henrique Rodrigues Vieira
• Naira da Silva Mansano

SCIENTIFIC INITIATION

• Nicoly Reis

MAIN ARTICLES

Mansano NS; Paradela RS; Bohlen TM; Zanardi IM; Chaves FM; Silveira MA; Tavares MR; Donato J Jr; Frazao R. Vasoactive intestinal peptide exerts an excitatory effect on hypothalamic kisspeptin neurons during estrogen negative feedback. Molecular and cellular endocrinology, in press.

Paula DG; Bohlen TM; Tessaria TT; Mansano NS; Vieira HR; Gusmao DO; Wasinski, F; Donato J Jr; Frazao R. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sciences, in press.

Teixeira PDS; Ramos-Lobo AM; Rosolen Tavares M; Wasinski F; Frazao R; Donato J Jr. Characterization of the onset of leptin effects on the regulation of energy balance. Endocrinology. V. 2;249(3):239-251, 2021.

Zampieri TT; Bohlen TM; Silveira MA; Lana LC; Paula DG; Donato J Jr; Frazao R. Postnatal overnutrition induces changes in synaptic transmission to leptin receptor-expressing neurons in the arcuate nucleus of female mice. Nutrients.v.13;12(8): 2425, 2020.

Bohlen TM; Zampieri TT; Furigo EC; Teixeira PDS; List EO; Kopchick; Donato J Jr; Frazao R. Central growth hormone signaling contributes to the timing of puberty in female mice. Journal of Endocrinology, Journal of Endocrinology. v. 243(3): 161-173, 2019.

Silveira MS; Zampieri TT; Furigo IC; Abdulkader F; Donato J Jr; Frazao R. Acute effects of somatomammotropin hormones on neuronal components of the hypothalamic-pituitary-gonadal axis. Brain Research. V. 1714:210-217. 2019.

Furigo IC; Teixeira PDS; de Souza GO; Couto GCL; Romero GG; Perelló M; Frazao R; Elias LL; Metzger M; List EO; Kopchick JJ; Donato J Jr. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons. Nature Communications. v.10(1): 662. 2019.

Lima LB; Haubenthal FT; Silveira MA; Bohlen TM; Metzger M; Donato J Jr; Frazao R. Conspecific odor exposure predominantly activates non-kisspeptin cells in the medial nucleus of the amygdala. Neuroscience Letters. v. 681, pg 12-16, 2018.

Bohlen RM; Silveira MA; Buonfiglio DC; Ferreira-Neto, CH; Cipolla-Neto, J; Donato J Jr; Frazao R. A short-day photoperiod delays the timing of puberty in female mice via changes in the kisspeptin system. Frontiers in Endocrinology. v. 9:44, 2018.

Silveira MA; Furigo IC; Zampieri TT; Bohlen RM; de Paula DG; Franci CR; Donato J Jr; Frazao R. STAT5 signaling in kisspeptin cells regulates the timing of puberty. Molecular and cellular endocrinology. v. 448, p. 55-65; 2017.